Brinkley Union Station is located at the site of the former crossing of the Rock Island and Cotton Belt railroads in Brinkley, Monroe County in eastern Arkansas. In addition to the Rock Island and Cotton Belt, the station also served branchline trains of the Missouri Pacific.
Brinkley Union Station was constructed in 1912 as a joint station to be utilized by all railroads passing through Brinkley. Cotton Belt passenger train service through Brinkley ended in 1959 and the last Rock Island passenger train stopped at Brinkley on November 10, 1967. Rock Island trackage west from Brinkley to near Little Rock was abandoned and dismantled in the mid-1980s.
After sitting abandoned for a number of years, Brinkley Union Station has now been restored and is used by the Central Delta Depot Museum. The station and nearby railroad hotel are listed on the National Register of Historic Places.